This report lists the winners of Subject Certificate of Excellence awards (formerly Certificate of Distinction awards) in 2021, along with the school that they attended.
These awards are granted by the School Curriculum and Standards Authority to the top 0.5% of students in each tertiary entrance subject based on their examination marks.
Special Subject Certificates of Excellence may be awarded to a student who is ineligible for a Subject Certificate of Excellence but who has otherwise satisfied all other requirements for the award.
| 1 | Accounting and Finance | Special Subject Cert of Excellence | Liu, Xiaona | St Hildas Anglican School for Girls | Mosman Park |
| 2 | Accounting and Finance | Special Subject Cert of Excellence | Too, Yuzhi | Sunway College | Malaysia |
| 3 | Accounting and Finance | Subject Cert of Excellence | Liu, Daniel | Rossmoyne Senior High School | Rossmoyne |
| 4 | Accounting and Finance | Subject Cert of Excellence | Singh, Kiran | Hale School | Wembley Downs |
| 5 | Accounting and Finance | Subject Cert of Excellence | Yeoh, Aun Tieng | Rossmoyne Senior High School | Rossmoyne |
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| 6 | Ancient History | Subject Cert of Excellence | MacKinnon, Jack | Christ Church Grammar School | Claremont |
| 7 | Ancient History | Subject Cert of Excellence | Tan, Nicholas | Christ Church Grammar School | Claremont |
| 8 | Applied Information Technology | Subject Cert of Excellence | Gribble, Jedd | Como Secondary College | Como |
| 9 | Applied Information Technology | Subject Cert of Excellence | Le, Nathan | Trinity College | East Perth |
| 10 | Biology | Subject Cert of Excellence | Boccardo, Alexandria | Kennedy Baptist College | Bull Creek |
| 11 | Biology | Subject Cert of Excellence | Cooper, Tyler | Australind Senior High School | Australind |
| 12 | Biology | Subject Cert of Excellence | George, Charlotte | All Saints College | Willetton |
| 13 | Biology | Subject Cert of Excellence | Gosper, Amalina | Perth Modern School | Subiaco |
| 14 | Biology | Subject Cert of Excellence | Jones, Lydia | Canning Vale College | Canning Vale |
| 15 | Biology | Subject Cert of Excellence | Pourshahmir, Seiedehartemis | Greenwood College | Greenwood |
| 16 | Biology | Subject Cert of Excellence | Ritchie, Bridget | Court Grammar School | Mundijong |
| 17 | Biology | Subject Cert of Excellence | Traverso, Emilia | All Saints College | Willetton |
| 18 | Business Management and Enterprise | Subject Cert of Excellence | Hepburn, Rhianna | St Marks Anglican Community School | Hillarys |
| 19 | Business Management and Enterprise | Subject Cert of Excellence | LEVINE, Rafael | Carmel School | Dianella |
| 20 | Business Management and Enterprise | Subject Cert of Excellence | Manning, Emma | Kennedy Baptist College | Bull Creek |
| 21 | Business Management and Enterprise | Subject Cert of Excellence | Singh, Charan Kanwal | Scotch College | Claremont |
| 22 | Career and Enterprise | Subject Cert of Excellence | Bayne, Bianca | Applecross Senior High School | Ardross |
| 23 | Career and Enterprise | Subject Cert of Excellence | Frampton, Alesha | Applecross Senior High School | Ardross |
| 24 | Chemistry | Special Subject Cert of Excellence | Liu, Xiaona | St Hildas Anglican School for Girls | Mosman Park |
| 25 | Chemistry | Subject Cert of Excellence | Beh, Lucius | Perth Modern School | Subiaco |